Brandon

But not just techbio. What do you do in terms of science?

Andy Beam

We are all in on the bitter lesson and scale. We think that methods that scale and that are general beat those that are not. You know, as Ilya said at Neurips last year, we have but one Internet. It's the fossil fuel we fracked. We got every ounce of data that we could out of the Internet, but it's gone. And so the question AI is like, where is the next Internet scale data set coming from?

Brandon

You know, people normally talk about different scaling accesses. You have compute, you have data. And for science, data is not necessarily an infinite resource. And your point is that we now want to add a new scaling axis for data.

Andy Beam

We think that like the lab of the future should feel like a data center. Rows of server racks as densely packed as possible and also as energy efficient as possible and things like that.

Brandon

Welcome to Latent Space Science. I'm Brandon, I'm here with my co host rj. Today we have Rafa Gomez Bombarelli and Andy Beam from Lyla Science. We'll just start off and let you introduce yourself.

Andy Beam

Yeah, yeah. Thanks for having us on the podcast. Like, you know, longtime listener, first time caller, excited to be here. I'm Andy, I'm the chief technology officer at LILA. I've been an AI researcher now for something like 20 years, going back to the pre deep learning days, SVMs, random forest, things like that. I did a Neural Net PhD around 2010-2014. Right as deep learning was taking off. It was clear neural nets were the thing to back but autograd libraries really hadn't been developed yet. So I did the back prop by hand back in my day, walking uphil both ways kind of thing. Got very interested in AI for healthcare and life sciences. My wife's a physician so I watched her struggle through different things and thought that AI was obviously a natural solution for a lot of those problems. Did a postdoc at Harvard in the medical school doing early work on medical AI and was really I'm in it for the AI. I was really interested in what problems could AI solve. But I've also always been startup curious. So I took a break from academia for a year and helped start a company called Generate Biomedicines which was an early generate biology company. I was the founder head of machine learning there and got to do the fun kind of hybrid professor, startup founder thing for the next five or six years. So I had a lab at Harvard again, sort of between the school of Public health and the medical school doing methods Research, but also a lot of applied work that was fun. Those are a great set of jobs. But I got a sense that the AI moment was changing in a very significant way and I wanted to be a part of it. So I started to think about where could I work at the frontier of AI on really, really exciting problems and act Academia has a lot going for it. Access to scaled compute is not one of the things that it has going for it or scaled resources. So I'd been an early advisor for Lila and got very excited once the thesis crystallized. But basically science has an infinite token generator to train models at scale. Why would I want to work on anything other than creating a new frontier model that can solve scientific problems? So I kind of joked that I hung up the tweed jacket two years ago, left my position at academia in academia and joined Lila Full as the inaugural cto.

Rafa Gomez Bombarelli

Yeah, I go by Rafa. I'm the chief scientific officer for physical sciences at Lila and a co founder. I was a computational chemist back in the day. We used a commodity resource that is compute. So it was clear that we could scale up compute to do molecular simulations. And that's sort of something that produced enough data that in the early 2000 teens we realized we had a data problem. And sort of things switched gear for me Right around then. I worked with David Dubenot and Ryan Adams in sort of blending what I think felt like the first instances of deep learning for science. I was one of the first people to do generative AI for chemistry with an autoencoder on tokenized molecules. And so I'm deeply in love with latent spaces. We actually have very similar to your guys logo but for molecules. And that has taken its own life. That figure.

Andy Beam

This is the one that will be on your tombstone.

Rafa Gomez Bombarelli

Exactly. My students have a Slack channel just to post it when it shows up in the wild. So not as much storied as Andy, but same convert. In the 2015, 2016 era, I spun out a company out of my postdoc at Harvard, a computational materials platform company, and then went to MIT where I started my group in material science and engineering. And the group there was sort of working at the interface of molecular simulations and AI with things like generative models for material structure, autograd for sort of really cool gradients that we want to see in molecular simulations. And by 2022, 23 sort of things were taking sort of the turn that Andy just mentioned. Right. We had seen the bitter lesson come to computationally generated data. And that's the reason why Meta and DeepMind and Microsoft, they have teams doing AI for computational material science. But it was clear that we needed to bridge a gap and get this thing all the way out and do AI for actual material science and not just the computational version. And that sort of lined up with this opportunity to start spinning out something again. Like I said, 22, 23 started sort of thinking about the idea. I'm very excited now to sort of been pushing this integrated vision of scientific reasoning across all the modalities of science we can validate in the lab.

Brandon

That brings me to what is Lila's thesis? It seems like you have a very ambitious goal here.

Andy Beam

Yeah, it's a great question. I'll try and give you the TLDR and then we can go a couple levels deeper. So like Rafa said, we are all in on the bitter lesson. And scale, we think that methods that scale and that are general beat those that are not. That actually sounds straightforwardly true, but is actually counterintuitive and contra to much of the 70 year history of AI research. But the realization that we had is that what gave rise to large language models over the last four, five, six years is the access of the combination of scaled compute and scaled data. That data came from the Internet, it was human generated and we have used it all. You know, as Ilya said at Neurips last year, we have but one Internet. It's the fossil fuel. We fracked. We got every ounce of data that we could out of the Internet, but it's gone. And so the question AI is like, where is the next Internet scale dataset coming from? Post the pre training era, we moved into reinforcement learning with verifiable rewards. So people talk about RL a lot, but really what RL is is a way for a model to generate its own data. And the reward signal reinforces good data and penalizes bad. So that has been a very productive framework for problems in math encoding. But at lylo, what we believe is that actually science running the scientific method and using nature and experiments as verifier is like the ultimate version of that. And so what we're building, we'll talk about these things that we call AI science factories. They are scaled verifiers for science so that we can do post training at scale and push out the frontier of what reasoning models are capable of. Um, so that's like the thesis in a nutshell.

Brandon

Your proposal is basically, you know, people normally talk about different scaling axis. You have compute, you have data, you know, you have parameters. And for science, data is not necessarily an infinite resource. And your point is that we now want to add a new scaling axis for data. So I want to quote some of my friends at the Escalante Bio have a blog post, really good blog post. I recommend you read it. It says your experiment has a runtime. So what is the runtime of your data collection?

Andy Beam

I mean, so that is an awesome question. It's so in. It will obviously vary by experiment. So, like, you can't make the ribosome go faster, at least to my knowledge there is. The biology sets a limit for how fast you can go. In material sciences and chemistry, there are smaller timescales, there are bigger link scales. What you're actually kind of asking is a technical question, though. So how do you train a model against feedback mechanisms that vary by orders of magnitude in terms of feedback? So we think about all of life as being able to generate different kinds of data on different link scales. We can then synchronize how we train the model once that data has been generated. Again, for some of the experience we do, the link scales are on the order of days or weeks. And the question is, can we multiplex? Can we get more data per unit time? But the infinite token generator is still there. We just have to solve the technical problem on the other side of that to be able to line all these pieces up and train it into the model.

Brandon

So when you say the infinite token generator is still there, what do you mean by that? Because there are many different scientific tokens you can imagine, and some tokens provide much more information than others. And certain things you can collect maybe at scale, like people who love ngs, you can basically collect an infinite amount of NGS data. Yeah. And yet there are certain cases where, you know, another human genome is probably going to be a, you know, an incremental update versus, you know.

Andy Beam

Yeah. Like my genome relative to a reference genome is like a couple of kilobytes worth of information. There's not a lot of information there. So you're exactly right. So we don't want to generate the same kind of data over and over again. And so the platform that we're building is qualitatively different than traditional automation frameworks. So actually, the experimental platform that we're building prioritizes generalizability and flexibility over raw throughput. We want the model to be able to design a new experimental protocol, run the protocol, and receive the feedback, even if that's not an experiment we have thought about doing ourselves. So it's the next incremental token, has to Be something that is valuable to the model versus yet another NGS sample to teach it something where it's already hit diminishing returns.

Interviewer/Host

So when you say next experiment, what I think of is traditionally you would go into the lab and reconfigure the lab in whatever way and then run some experiments by hand, maybe over the course of weeks or whatever. How does the lab get reconfigured for the new experiment at Lila?

Andy Beam

The way to think about the lab is it's almost like a graph. And so each instrument is a node in this graph. And an edge between a node indicates that there's a physical transport layer between those two instruments. And so we'll probably have a video that we'll show in a bit, but we have a physical transport layer that connects almost every instrument that we have bought at LILA to each other. These are currently planar motor Systems where there's a 96 wall plate that magnetically levitates over a track. You have sort of millimeter control over where that plate goes. And so you can. I think of it almost as like a PCI bus where each instrument. I'm not short on analogies for like the lap durability.

Interviewer/Host

That's a good one.

Andy Beam

Yeah.

Brandon

I think half of the audience might not know what a PCI bus is.

Andy Beam

Yeah. So it's a universal serial bus that on your motherboard allows you to connect a new device. So if you plug a new graphics card, if you plug a new hard drive in, there's a bus that allows that device to connect, speak to the rest of your computer.

Interviewer/Host

And this works for like bio systems and material systems and et cetera.

Andy Beam

Increasingly, but not totally yet. So the other thing to keep in mind about automation is there's a very long tail of things that you have to solve to be able to automate. And to date, people have not been thinking about end to end automation in this like, flexible kind of way. And so there are instruments that are not connected to this. Now there's not a lot of high throughput automation and material sciences, for example, and we've been building custom instruments for that then are brought onboard. But there's like an 8020 rule at play here where things that are easy to onboard and automate are plugged directly into the PCI bus. And then things that are not people still move. People will still move a sample to that. Or it turns out that removing a cap from a test tube is a very hard thing to automate. Like a lot of the lab assumes that you have opposable Thumbs and you're good with them. And some of the things that we've seen discussed about. Lila frames us as an automation company and that's like kind of the wrong perspective to think about what we're doing. We're not automation maximalists. We are actually sort of like token generation maximalists and flexibility Maximus. So we will over time automate things that make sense to automate and then again use solutions now where they make sense.

Interviewer/Host

So the, the system designs the experiments, it gives instructions. There's like, oh, people need to actually do this thing. So you get, you recruit some of the staff to go and do that thing.

Andy Beam

Everything's an API call. And so sometimes when you call an API, there's a robot arm, sometimes there's a, there's a human arm that something

Interviewer/Host

who are literally below the API line.

Andy Beam

Yeah, I think that like again, we want to spend resources where it makes, to spend resources and make rational decisions. And sometimes it just doesn't make sense to try and automate a step when a person can do it in a tenth of a second. But what matters is that the model has the ability to give instructions to test a hypothesis and that all of that data is visible, transparent, stored, so that those tokens flow back into the model.

Brandon

Do you have your AI models doing entire experimental designs which are beyond just a pre existing protocol where you tweak relative ratios or sources from or what oligos go into a pipette or something?

Andy Beam

I mean, it depends on your threshold for novelty here. Certainly for expression protocols. For some gene editing work that we've done, we have tested the platform's ability to do that versus humans. Model gets like 80% of that zero shot. Humans get zero percent of that zero shot. Are we doing like fully open ended freeform experimentation now? I mean, no, not yet. That is the goal, but we're building towards that. That is the end state that we want to be in. But we have seen the ability to do what would be an enormous amount of human intellectual labor over a very, very short time horizon.

Brandon

So when you're giving these, you know, giving your AI models kind of free rein to start designing new experiments, like how do you make sure that these are things that should be measured or that you validate that this is, you know, a good strategy or that you didn't just waste a bunch of money.

Rafa Gomez Bombarelli

The first one is there is I think maybe an underlying safety question there. And I think that we've been taking very seriously from the beginning.

Brandon

Right.

Rafa Gomez Bombarelli

Both security and safety. Security of the data and the safety of the model suggestions, we have a very strong team. It's growing under sort of very strong leadership. And that's the first layer. Right. Like we have strong safety AI safety protocols that look similar to the sort of uplift considerations that people have been looking into. Large language models only it's absolutely. We have strong AI safety protocols that look similar to the sort of uplift considerations that people have been looking into. Large language models only it's absolutely for real.

Brandon

In a lab automation setting where you're working on some, you know, biophysical material science type problem, what are actually the dangers you have to worry about? There's like I generally think of malicious actors and or you know, situations where you have a sufficiently complicated system that it could genuinely output something dangerous. It seems like from the scope of LILA as I understand it, which we haven't talked about yet, maybe it'll come in a minute. It doesn't seem like safety is actually going to be a major concern at this point.

Rafa Gomez Bombarelli

I mean it's something we need to take seriously from the beginning. Right. Something where we cannot afford to not get it right. I agree with you. Right now it's in the hands of LILA employees that are sort of whose interests are aligned and whose understanding of the platform is aligned with our mission. So I agree we don't have to worry about malicious actors. We still need to worry to some degree about the model giving a suggestion. I think it's more some things that start touching into lab safety more than malicious. I don't think we're going to have emerging behavior where the model suggests an extremely toxic chemical. It's more about pushing an instrument such that maybe it overflows, it combines chemicals it shouldn't have. So I think there's a chemical EHS safety layer that needs to be there since the beginning because we're doing sort of open ended.

Andy Beam

I do think RAF is right in that safety is not something you can procrastinate on because capability curves tend to be sigmoid shaped and it can look like everything's fine and then all of a sudden there's something that you didn't anticipate the model being able to do. So we are definitely proactive on that side. We have an AI safety team like Rafa said. But I think you're also right in that we can constrain the problem in meaningful ways in the way that a broad based AI system that interacts with the general public cannot. We can also lean on biosafety levels and things like that. That good old fashioned lab Safety to help in the meantime.

Rafa Gomez Bombarelli

And of course, the nodes that are exposed to a particular. We don't necessarily need to expose all the experimental capabilities to all the scientific questions.

Brandon

Right.

Rafa Gomez Bombarelli

For an antibody design question, we probably don't even need to expose the model to the fact that we have gas canisters that contain gases. Right. Because it's not going to need them. So we can still be creative within sort of questions that relate to one particular area of science.

Brandon

Yeah.

Andy Beam

So your question though is, sorry, is interesting, like how do you know if something is dangerous, is actually kind of hard to do, or actually how do you know if it's wasteful? Some of the work that we've been doing in electrocatalysts, we have someone inside of lila who's published 40 papers on the topic. And some of the suggestions from the model initially were boring, but then transitioned from boring to what he considered to be stupid. These are non platinum group electrocatalysts for separation of hydrogen, oxygen from water to make hydrogen. And those turns out to be our best non platinum group electrocatalysts that we've made. So the line between obviously wrong and like quasi move 37, surprising even to a human expert is hard to know. And so we, we will do wasteful things because we kind of want to know the difference between, between the two

Interviewer/Host

that brings up the question. So for like an experiment like what you're describing now, it is obvious whether it works or not. Right. But you can imagine, and there was some controversy in previous at the Berkeley lab around measurements that were misinterpreted.

Andy Beam

Right.

Interviewer/Host

How do you know that your measurements of effectiveness or whatever you're, you're optimizing are actually correct?

Rafa Gomez Bombarelli

Yeah, I'm very familiar with that part of, of the landscape. I would say we cannot relax our standards of scientific rigor because it's AI, right? It's not, you know, maybe five years ago when, you know, we started doing genetic models for X and Y, they were like, yeah, it's cute. It kind of works like you would do with a kid. It's like. But now we're past that and we need to hold AI science to the same standard we hold regular human led science. I think that 2023 paper was a switch over from the community, a part of the AI community, AI for science. People were always excited to see incremental progress. And I think at that point we started collectively touching upon the rest of the community's awareness and they were like, fantastic. But now we're going to talk about the way we do things. To our highest standard. So I think we have lots of experimentalists and I want to go back to the API point. I think we've had the fortune by starting from zero to build a company where people are sort of AI aware, AI excited. We have sort of, across all the people and the networks that I've collaborated with, we've managed to build a team of experimentalists and automation engineers that really believe in the mission and really want to make it happen. They're really taking this graciously. So whenever AI gives something that is sort of very, very wrong and they're there to just, okay, they push the red button, watch out, this is a bad idea. But they're also gracious in, for instance, trying false positives. False positives are terrible for human scientists, right? Because you go to try something, it doesn't work for the model. It's fantastic. It reduces uncertainty a lot. For the operator, it's kind of a bummer, right? Because you thought you were going to get something cool. And I think we've managed. And going back to the point Andy made for the, you know, I think about, until three months ago, people would be sort of approving AI decision. And I think about three months ago, we started seeing that the model's crazy ideas started being sort of surprising to people, but surprisingly good. It's like, I don't know, I guess we need to try. And we've seen the switchover. So I think the ability of people, experimentalists to sort of challenge the AI, but being gracious, that interface of human and computers has been very rewarding over the last few months.

Andy Beam

I'll also say, like, giving the model control of the lab forces you to build infrastructure to expose pieces of data that you wouldn't normally want to or care about. And maybe no experiment is wrong, but you want the ability to explain the outcome. So if you think about, if you have an experiment, you fit a statistical model, what you're trying to do is use variation inputs to explain variations in outputs. And so we have the ability to explain variation in outputs because we measure so many different things, because we have to expose that to the model so we can say, okay, the humidity was off in the lab that day, maybe that explains exactly the thing. And then we can also push button and rerun the experiment to verify. And so we do not believe, like Rafa said, in some sense we have to be more skeptical of any outcome. But we can then quickly go and rerun that experiment because it's all software effectively.

Interviewer/Host

And you find that the team spends a Lot of time on verification or like, how's the breakdown?

Rafa Gomez Bombarelli

Less and less. So I think at the beginning it wasn't so much. I mean, there is an execution of, okay, we've got a hypothesis, we've got a set of instructions that's going off to the API. We vouch for it. And then some parts of the API are people doing things. And I think that will stay right, like the labor of it. But I think the double checking that the intuitions were right. I think we're starting to see this super intelligence local spikes of places where we're kind of supporting this emergence of super intelligent behavior more than we are sort of gatekeeping and that the ideas are not just wasteful. So I think that's happening for domains and maybe to elaborate a little on the example that Andy mentioned, we care a lot about energy and sustainability. Something that. And we're not just a biotech. We really care about energy and sustainability and materials. We're trying to make green hydrogen. And in order to make green hydrogen, you need to use light to split the water molecule. A bunch of that energy you need to pay for because it's the energy that's stored in the chemical bond and that you get from sunlight and electricity. And then there is some overhead that you pay that's called the over potential, which has to do with the fact that the world is not perfect and things are lost. And the loss comes from something called the catalyst. And today the catalysts that are out there are okay, but they're expensive and rare. They're made out of ruthenium and iridium. So we set up a model to explore what can we do to not use these two elements. And people do these papers and there was something a couple of weeks ago that said ruthenium, low ruthenium alloys for xyz. Well, I mean, yeah, it's like, sure, you can can dope it down, you can water it down, but it's still the same fundamental problem. You're just using 50% less. So we've set out the model rules on this type of problem. And we have the ability to make the material, measure the properties, measure the catalysis, measure the stability. And then in the second third generation of sequential learning, this interplay between information and what the model knows, we started seeing suggestions that were like, I mean, the words were fine. It was using the concepts that we use. It's just that, you know, I wouldn't apply that idea to that element. I wouldn't have put them together in that way. And it turns Out. Those have been our best performing chemicals so far.

Brandon

I do want to get to the Lila is not a biotech. But before we do, one last question along the thought train. RL is famous for reward hacking. You just. I forget what you said. I don't know if you said you were using RL or you know, learning iterations. I would be very concerned that, you know, you throw some rewards and that you can really hack the, you know, physical sciences in a way that you can't do with the compute.

Andy Beam

Yeah, I'm not going to disagree with that. 100% agree.

Interviewer/Host

What's the funniest example?

Andy Beam

We have lots of funny like RL fails that are not explicitly reward hacking. Well, I mean, one is when we trained, one of the early things we did was like, can you just like make a plate map? Like, can you like, like lay the experimental conditions out on a plate? And it got annoyed when the person would ask. So you would ask the model to do a plate map and it would do it and they'd be like, actually, could you change these reagents? And it would like swear it would be like, it's a 96.

Interviewer/Host

Well plate.

Andy Beam

Come on, man. Like it's not a 94 like in the chain of thought. I don't know where that came from, but it was like somewhere on the Internet. Yeah, somewhere the Internet's in there. I can't forget that. So we've seen lots of like funny personality quirks like that. As a function of rl, there's obvious rl. I wouldn't call them reward hacking, but pathologies like repetition. So the chain of thought will collapse and it will just repeat its final answer over and over and over again. For some reason, that reliability sometimes leads to higher rewards. We're not sure exactly why pathological chain of thoughts, or non legible chain of thoughts in some cases lead to higher rewards.

Interviewer/Host

So sorry, I want to interrupt. So we're talking about rl. Yeah, we're talking about the way way you're talking about it sounds like just RL on chain of thought, just like everybody's doing. But your RL actually has a lab step.

Andy Beam

Yeah.

Interviewer/Host

If you're in a pathological loop, does that mean the lab is just like doing the same experiment over and over?

Andy Beam

It's just not. So a chain of thought, maybe just to step back, is tokens that the model uses to solve a problem. So if you were solving a math problem, you would do Theorem 1, Theorem 2, Corollary Lima, you know, you decompose problem in science, the Chain of thought, there's some of that too. So there's reasoning that happens. I'm trying to make an antibody for this target. What do I know about this target? What are the known epitopes? What's my plan of attack? In the chain of thought are also tool calls. So maybe I'm going to use a structured prediction model in this case to get some read of how the sequence folds in three dimensional space. So tool calls are part of the chain of thought at Lila. The fun thing is that the lab instruments are also tool calls or a series of tool calls for a workflow. But it's all cumulative, human, legible, it's all in English. And so some of the pathologies we've seen is it just skips all the middle part, which we would think is important for solving a problem and just goes right to the answer and says I don't need to do an experiment in this case, I don't need to call a tool. And in some cases where we can judge something because maybe we've already done the experiment or something like that, for some reason it is actually not a bad strategy in some cases. And so there's some mystery there.

Brandon

It's a theorist.

Andy Beam

Yeah, it's done the calculation and this is probably too much of a tangent, but like it actually thinks in latent space, it emits tokens. So like the chain of thought is often an unreliable narrator for what the computation of the model is actually doing. And so one of the big things we're trying to think about is when we're moving into working on a problem, you know, like Rafa said for electrocatalysts, that we actually don't know what right and wrong looks like. How much should we rely on the chain of thought versus just trusting the experiment, trusting the verifier, trusting the simulator as the ultimate ground truth, truth.

Brandon

So, you know, Lila is not a biotech company. Lila is actually fairly unique I think, in this way.

Andy Beam

You know, I've been involved with biotechs, I've helped start biotechs. Often the goal is to sprint to a clinical trial. So you want to develop an asset. You develop a platform in service of having optionality of what space you move into. But once you do the, you have the clinical asset, put everything into a medically induced coma and you get through the clinical trial. And if it goes well, then other things get to. So we are taking that option off the table. The model itself is the thing of value at Lila. So in that sense we're much more of like A neolab trying to think of a new way to push forward capabilities of a core reasoning LLM based model.

Interviewer/Host

Not even the lab platform.

Andy Beam

So the lab platform is the token generator, okay? That is the data generation mechanism that ultimately is the moat for Lila is that once that continues to scale, the amount of data that we can generate both per unit time but per unit square foot will go up and that feeds back into the model to make it smarter that then suggest the next experiment to do. And so we really are focused on making this core model as performant and smart as possible. And we can talk about how that lends itself to different commercial strategies. But ultimately we're interested in creating this new type of AI model.

Brandon

So I want to quote Sri Khosuri from OctantBio, who had a great tweet I really loved a few weeks ago. What is the business model in ML for drug discovery? Because if you need the data to train the model, but if you have the data, what do you need the model for?

Andy Beam

That is true when you are narrowly scoped. So that is true within a given vertical of science. The analogy that I would use is like if you went back 10 years and you tried to create like a coding assistant model, you would just get coding data. You wouldn't also get Shakespeare, poetry, carnitas, recipes. It turns out that there is spillover as the model is able to train on a broader swath of data and a deeper cut of data. And so again the core bet that we're making is that is true for science, that if the model is trained on an increasingly broad set of data, the amount of data that you need in a given domain, that data requirement is reduced in some cases will be reduced to zero if it's adjacent to what the model has already seen before. And so there's a data efficiency argument that would suggest that again having a general platform that can create a broad swath of scientific data. I'll also just mention that obviously we are using things that are already commodities. So public, public data sets we use, simulators we use, and the experimental platform is a complement to these existing commodity resources.

Interviewer/Host

This brings up a question in my mind about there's a concept of applicability domain where you have different scales, different, and they result in different types of completely different types of information and relationships between entities. Right? So you have the, the, the quantum realm, you have chemical realm, you have, you know, sort of different biorealms. One concern I would have with cross cutting approaches is there domain transfer between these at all. Whereas you know, carnita's recipes and you know, chest problems have the commonality that they're written in language, whereas you almost have a completely separate, not even language. Right. It's a completely separate model between these domains.

Andy Beam

Human scientists work on all of those domains. Correct. And they mostly communicate with each other in written language using tools. So I would say there's a common reasoning process that allows someone to solve problems in each one of those domains. And so I think that that logic carries over to a reasoning model that we're training that again uses tools, can do math, can do code, but it's having all of that knowledge stored in one place.

Interviewer/Host

One classic example for me of domain transfer is between complexity theory and quantum gravity. Right. Where now a lot of the quantum gravity theories are basically recognizing the identical math behind the two of them. Right. Do you have examples of this kind of sort of. Oh man. This domain actually applies to this domain.

Andy Beam

So we have assembled this reasoning data set of 10 trillion scientific tokens, reasoning traces that are experimentally verified across life sciences, chemistry and material sciences. And we have seen that this general model often beats the domain specific models. And so it's hard to point to what's in the model that is making it, what connections it has realized. But clearly having seen more data across all of science beats sort of in a sample for sample kind of way domain specific reasoning models.

Interviewer/Host

The future of, of science is language, right?

Andy Beam

Well, so yeah, so I don't know,

Interviewer/Host

it's future of chemistry maybe.

Rafa Gomez Bombarelli

I don't think it's necessary. I don't think that's a necessary condition for a scientific superintelligence. I mean, there was this quote from Demis Hassabis what last week that it might not be worth distilling all the ways that live in sort of protagonist or alphafore there are data modalities that are so different from language. And you know, Andy always tells me, well, Rafa, English is Turing complete. So you could express everything.

Andy Beam

It had been several Turing complete languages,

Rafa Gomez Bombarelli

but yes, yes, so and I agree with that. There might be places where it's more efficient because of the nature of the. I mean you've done geometric deep learning, right? I think for geometry and maybe, you know, I call my colleague Testmead. I think geometry is one of those places where people feel that there might be sort of just the nature of the problem. Problem is more amenable to other architectures. So if we need to call a protein folding model or we need to call an equivariant diffusion model to make crystal structures that's fair game. So I would say the future of the way science talks with us for sure is through language, that the model needs to be thinking in English about chemistry all the time? Maybe yes, maybe not. Chemists don't think about chemistry in English.

Interviewer/Host

Okay, yeah. They talk about it in English.

Andy Beam

Yeah, exactly. And, and I agree with everything Rafa said. Token based reasoning with tool use is very powerful and I think the claim that we're making is we have barely scratched the surface for that in science. We're not trying to distill domain specific models into a reasoning model. It can use those tools productively. And so it's just the combination of reasoning, often in English, but also in Python and things like that combined with tool use is very powerful. And we're very early in science and understanding how far we can push that forward. Forward.

Interviewer/Host

I see. So can you give some examples of campaigns that you are running that are representative?

Brandon

And actually before you do that, I realize we still haven't explained that you don't just do bio.

Andy Beam

Right?

Brandon

Just in your tech bio. So I think this is a great lead into this. So not just tech bio, what do you do in terms of science?

Andy Beam

Science, no. So maybe, yeah. So the way that we train the model is, I mean it's across life sciences of DNA, rna, protein cells, small molecules, different kinds of chemistries and different types of material. So that is like where we're scoped now, which is admittedly a large scope.

Brandon

Materials itself is also not just. That's also as largely scoped as everything in the bio.

Rafa Gomez Bombarelli

We can give some examples. So today we can make thin films, we can make powders, we can make quantum dots. We have acute quantum dot. Are you folks familiar? Quantum dots are the luminescent technology in some TVs and you need to control to make them of exactly the same nanometer size. And the nanometer size you make them controls what color they're going to be. And you need the purest red and the purest blue and the purest green to make really sharp and rich color palettes for your tv. And you need to make them as homogeneous. They all need to be the same, otherwise the color gets again blended. So we have a cute demo where our self driving lab, we ask our visitors to pick a wavelength, what color you want the quantum dot to be when they come into the office. And then we fire off the machine. The model reasons even sometimes we even throw in new chemicals that the model had never seen just to see how it moves. The machine is running and by the end of this sort of hour, hour and a half tour, the machine has made maybe one, maybe more generations of quantum dots that tend to hit, otherwise we wouldn't do it right, tend to hit the color that people suggested. So we have the ability to make lots of materials. We can formulate liquids and polymers and so matter. We care about energy and sustainability a lot. So we have a good chunk of electrochemistry capabilities, about the interplay of chemical transformations and electricity as a renewable energy source. We care about traditional catalysis and we care about mechanical properties of materials. And all this comes together in programs where we make catalysts, we make high performance coatings for corrosion or aerospace, high performance mechanical applications. And over the last few weeks with an external partner, we started multiple sprints of things we weren't doing before that touch from adhesives to cooling fluids. So we've been able to sort of more and more spin up just exciting discoveries in sort of open ended chemistry and material science spaces.

Brandon

Do you have any connection between quantum dots and let's say protein design?

Andy Beam

It's the same platform that does that. It's the same set of capabilities. And so there's a shared infrastructure that lets us do all of those things under the same roof. If there were no connective tissue, then our ability to do, we just would not have the ability to do all those things. Have we done like the mech and terp thing where we look inside the model and see does this insight from electrocatalyst inform? We haven't done a deep dive on the mech and terp thing. We have seen that our ability to do these programs has gotten faster as the platform has become more mature.

Brandon

So is LMP just like a common thing along? Is this something really common in your toolkit? Toolkit that because of this, this enables like a large fraction of these ideas that you've just mentioned. It certainly makes sense on the bio side, but I know bio much more than materials. Is that like a common theme amongst

Rafa Gomez Bombarelli

your lab toolkit, the AI science factory? The more capabilities has, the faster we've been able to go after new target product profiles and about new exciting opportunities because the model is prepared to do more things, things the lab can do more things. Our scientists are more flexible and faster in order to incorporate new capabilities. Adding new instruments has become faster the more instruments we have. So maybe echoes with sort of what type of company we are. There is echoes of hyperscaling here, of this sort of scaling in software is backed by scaling in hardware. And the fact that we have sort of Tens of thousands of square feet of labor coming online with dozens to hundreds of instruments is giving us this breath to move fast. There are places you folks had my colleague Heather Kulik here in the podcast recently. One of the areas you work in the sorption. I think the audience will be familiar with these materials. I don't need to spend a lot of time introducing them. These materials are made of the interaction of a molecule with a metal. And it turns out our model had been trained on small molecule drug discovery and all of the chemistry that they had learned thinking about drug discovery carried over to start reasoning over these metal organic framework materials that we can use to take CO2 out of the air or to filter ammonia.

Brandon

I find that fascinating when I think so many times I've seen people work on machine learning where they train some big data set and then they move to some new domain. And oftentimes the amount of transfer you see is, is small.

Interviewer/Host

So are there like a group of, I don't know how to say this. Primary colors that you have that you combine together that oftentimes result in your experiments.

Andy Beam

So on biology, they'd be the obvious candidates. Nucleic acid competence, self re expression and then downstream assays were things that we care about. So there are core competencies that we can then, you know, sort of give rise to a factorial number of different things that you can do. And on the material side, I think

Rafa Gomez Bombarelli

formulation, and it wasn't even. It's so, I don't know, I don't want to say, you know, mundane, but it's so common, it's so important that it wasn't one of the first sort of, you know, super intelligent places. We thought of flashier things back at the beginning. And it turns out a lot of people, you know, in industry and in the rest of the world care about formulation, meaning mixing liquids and gooey things to make other gooey things. But that's lubricant, that's sleepy nanoparticles, that's deodorant. There is all these things in consumer products and industrial products and in medicine gels to skin grafts, all those things emerge from this sort of mixing gooey materials. And that's a muscle that we're building. That's a very common platform that is showing up all the time the more we talk with people.

Interviewer/Host

Interesting. I have a rule of thumb that I often use when I'm thinking about scaling, which is that every time you scale an order of magnitude in a system that your set of problems completely changes. You guys pick the two hardest problems, right? Materials and, and bio, you do other stuff, but materials in bio are notoriously difficult to get to market, right? It, you know, 10 year, 15 year time horizons. And the reasons are especially for materials scaling. So how are you thinking about that? Are you just saying word discovery? Are you saying that we'll get to it? Like what? How are you thinking about it?

Rafa Gomez Bombarelli

The last academic lecture I prepared before I stopped giving academic lectures called the Bittersweet lesson of scaling in Materials and Chemistry. Because it's this, it turns out, you know, in AI, scaling is a good thing because it gives you a roadmap of what you need to do. And in chemistry and materials, scaling is a spooky thing because it turns out only the things that you can scale matter. So we're extremely cognizant, right. Our product team, our lab team, we all know, for instance in the quantum dot example, we've been able to use the same recipe from single digit milliliters to 100, almost a liter. So there are places where, you know, our capability today takes bites into scaling and into technology readiness level. Then we are making the system such that they can reason about what's going to matter later as they're doing the experiments now. And this would be in our rare earth 3 or sort of platinum group 3 catalysts. Precisely. The nature of the question is that we need to be able to scale this. So it's supply chain conscious as we're firing off the first experiment. We've already read every paper, we've already have a techno economic analysis agent sitting on the corner ready to do the techno economics of anything we do. At the end of the day, we're not going to do clinical trials, we're not going to make pilot plants for one particular process that you will put in your refinery right at that point. These are places where we will work with our customers. Or if we find something so amazing that we don't even need any instruction and we just go sell it. But typically we will hand off. Just like we're going to support therapeutic discoveries for our customers, we're going to support materials innovations at the pain points that our customers have. And those also have to do with scale scaling.

Interviewer/Host

How far have you gotten so far?

Andy Beam

So on the life sciences, and I think I agree with everything Rafa said there, the way to think about like how people would use the platform is or like just kind of like what we're building is much more of like a Claude Codish kind of thing for science. So one of the things that has Drawn early customers to us is. So we're not an nvivo car T company. There's lots of in vivo car T company companies. Super hot right now. We did see, you know, six months ago with the capstone acquisition for like, two plus billion dollars. If folks aren't familiar with that, like, in vivo car T is this very new heart therapeutic modality, previously for blood cancers, but now increasingly for autoimmune disease. We did have in the internal, like, sort of triumvirate of capabilities that you would need to do in vivo car T. So binder design. Obviously we can do that LNP formulation and then MRNA design Just so people

Interviewer/Host

know what car T is. It's really freaking.

Andy Beam

No, I love it.

Interviewer/Host

It's so cool.

Andy Beam

Can I talk about Car T? So Car T has been worked on since the late 80s or 90s. Really caught fire around 2010 or so for cancers. The way it used to work is you'd extract someone's T cells. You would engineer what's called a chimeric antigen receptor that goes on top of that. That tells the T cell to what go in to go what kind of cell to go and kill.

Interviewer/Host

So you're basically modifying people's T cells, take them out. You modify it so that it has this weird on its surface to seek and destroy tag.

Andy Beam

Usually they use a protein called CD19, which is preferentially expressed on B cells. When B cells get malignant, they create blood cancers. They create autoimmune diseases. You wipe out someone's Almost their entire B cell repertoire. When you do this, there's a lot of collateral damage, but essentially you're telling the T cell what to go and kill. So this really started to catch fire around 2015. It was expensive and slow. You have to extract someone's T cells. You have to engineer them. It's like $400,000 per, but still a miracle cure for lots of different types of cancer. Too much of a tangent for this. But there's this child named Emily Whitehead who was treated at the children's hospital of Pennsylvania. Chop. She was one of the first cures in pediatric cancer by car T. She was going to be referred to hospice care. Got car T. Another side tangent. She almost died of a fever from this initial car T treatment. The only reason she survived is because the doctor who was treating her had a daughter with pediatric arthritis and knew that this specific antibody would blunt her IL6 response to Car T. So there's a lot to unpack there in terms of AI for science. All the serendipity that had to happen in that specific case for all that to go, right? Probably. If you roll that dice a thousand more times, you probably don't get that doctor at that moment who knew exactly what antibody to give her to make that treatment curative instead of lethal. So again, those are the types of serendipity things that we'd actually like to automate. So anyway, it was slow, inexpensive. People then realized that actually through j just an infusion, if you take an MRNA that encodes for the chimeric antigen receptor, you put it in a ball of fat called a lipid nanoparticle. You put a CD8 targeting moiety on the outside of this ball of fat, it will then you give them the infusion, it will go bind to the T cell, get ingested. Ball of fat dissolves, mRNA, comes out, chimeric antigen receptor gets expressed and presents on the top of the T cell.

Interviewer/Host

So you're just telling, you're reprogramming the T cells to express these weird antigens, literally programming biology.

Andy Beam

And then the T cell goes and does its thing and wipes out whatever has cd. So malignant B cells explain a lot of blood cancer. They also explain a lot of autoimmune diseases. B cells often make antibodies in response to autoantigens and things like that. So recently, six months ago, as the result of about six years worth of work spun out of a Nobel prize winner's Lab and about $100 million worth of R and D, we saw. That's some good music, man.

Brandon

R and B.

Andy Beam

And we saw some of the most compelling preclinical data for in vivo CAR t treatment of autoimmune diseases. It was by a company called Capstan. They were bought by abbvie for like $2.1 billion. So at Lilo, we had been working on all three of those things in isolation. So about six months ago, a team of two or three people inside of Lila tried to see what we could do in the in vivo car t and what we had been working on was MRNA design. So like most RNA medicines, the biggest knob that you can turn is express expression peak and expression durability. So how many proteins do you get per unit of MRNA when you give someone a vaccine or some other MRNA medicine? So we have developed some monster UTRs, untranslated regions which flank the protein coding region which dictate those expression properties. Something like 10x the references from Moderna and Pfizer. And over the course of six months got to in vivo data in non human primates where B cell Depletion was significantly better than what was shown in the capstone data. And the sort of like durability of that was also. All the characteristics that we looked at were significantly better. Having more CAR expression is probably one of the most potent ways to improve a CAR. T therapy, the number of receptors that get expressed dictates how likely that T cell is to bind to the bad cell once it finds it. And T cells are literally serial killers. And that they will go, they'll kill a cell, then they'll go the next one, the next one. And so how long they can do that is dictated by how durable the expression of the, the CAR is. Again, we're not a car T company. We're science nerds. We like to do cool stuff. So we got to that proof point in about six months where again, all the way up to where you might think about filing an IND for a new clinical asset. We're not going to do that, we're not going to do a clinical trial. Again, that would be all encompassing. But some folks who had been around Lila for a long time saw that as a way to do essentially like a two to three person FTE startup where there's a couple scientists who have domain knowledge and a combination of the model plus platform can do five years worth of biotech work over a six month period for 10% of the total investment. And so a lot of the commercial relationships we're thinking about now are essentially like the zero FTE startup model where someone comes with an idea, they say if there was a car T in the market, that could bind to two things. If it was a bispecific or if it had these other properties, I know the hole in the market that that thing would plug into. And so a lot of our commercial engagements are effectively virtual startup startups running on ly now where someone comes with a very well specified problem, they don't know how to get there. There may be some things related to target identification and things like that too. But they can effectively run that entire program over a much shorter amount of time with at a fraction of the cost.

Interviewer/Host

And so those are, those are like a partner comes to you says I have this idea, I don't want to build a, I don't want to build

Andy Beam

a lab, I don't want to hire team, I want to get, I just

Interviewer/Host

want to get it done.

Andy Beam

Yep.

Interviewer/Host

So it could be some academic at a university that's like I, I have this idea, I kind of did a little bit of validation.

Andy Beam

I think it'll work.

Interviewer/Host

Can I do it? Can I sit with you guys for six months and make it work?

Andy Beam

Yeah, I mean that, that's the right way to think about it. Yeah. The way that like contractually it plays out is there's like a platform access fee. There's like we have to pay for reagents and running the system and then some overhead and stuff like that. And then there's like some upside sharing. That is a scalable model where we can service as the platform gets better. Instead of doing dozens of those, we can hundreds and then thousands of simultaneous kind of virtual startups being developed on the platform where we have revenue that helps pay the bills in the near term. But then we also have this upside partnership with folks who decide to build with us.

Interviewer/Host

That's amazing because this is what we're seeing is that people are more and more pushing towards getting rid of all the extraneous infrastructure and using automation and focusing on the idea.

Andy Beam

I mean, the way that I think about it is like most of us got into science because we're curious and want to answer questions. I'm a computer scientist by training and I like to answer questions through software. However, if I had to program in binary, I would enjoy that significantly less. There are high level abstractions, increasingly high level abstractions used to just be Python and Java. Now it's like cloud code. They help me answer questions faster. The analogy is that scientists are still programming in binary. They have a question that they want to answer, they have to just compile that down to an experimental protocol. Then they have to go and do the manual labor and get arthritis by moving liquids from one. That's the equivalent of scientific programming in binary. And so we're trying to help scientists move up the abstraction ladder where what's the like, you know, maybe your idea isn't going to work. Most clinical trials fail, but you can at least get to failing fast if you don't have to do both the physical labor and also some of the intellectual labor to, you know, get all the pieces in the right place.

Interviewer/Host

You know, most clinical trials fail. You know, somewhere between 5 and 8% of clinical trials actually get from IND to approval. So the, the discovery is not actually the constraint. I was interested. You were talking about the sort of economic modeling agent. I can't remember what exactly you called it, but I mean, that seems like the problem to solve. How do you think about this?

Andy Beam

The pro. You mean the, the success rate of, of clinical trials?

Interviewer/Host

Well, the economic model underlying what scaling

Brandon

in general for both bio and materials, like oftentimes there's this huge, huge, huge process like once you have something which is you consider final, like a, a IND or development candidate.

Andy Beam

Yeah.

Brandon

For, for material like there's still usually like 10 years of clinical trials or you know, qualification in the material science world to just get that into a product. And yeah, oftentimes the bottlenecks there are things about scale manufacturing, about regulatory, about safety and things that are oftentimes just very hard to answer upfront. So every time you do this, you just have to, you know, you know, roll a die. And there is the typical if you will deal with this is, you know, essentially a portfolio model, you know, financing wise. It's, it's very much a. You know, the only way you can make money is if you scale with some level of like, you know, risk calibration.

Andy Beam

Yeah.

Brandon

You know, it's really exciting to hear that you can do these things specifically. But how does it feed into the larger thing where even if you solve these problems immediately, it's still only 10% of the problem.

Andy Beam

The reason why US biotech is losing to Chinese biotech is not because of an innovation problem. There's a regulatory framework too that has to go to enabling fast clinical trials. The FDA has made motions towards that recently, both for the pre clinical data that you have to submit in some cases, but also how we will run and monitor trials. So it'd be crazy to think that one company or even like any company combined could change that on their own. So it has to be done in tandem with the regulators. However, the minor moves in preclinical probability of success matter a lot from a portfolio theory perspective. It makes investment much more attractive. It means in expectation medicines get to patients faster if fewer of them fail. And so I would say that is the area that we're focusing on now is that a medicine created by a system system that has had the benefit of in this case a million unique MRNA designs to maximize things that are known to translate to therapeutic benefits will meaningfully move those pre. It's still, you know, I guess I'd say it's better to throw a loaded die than it is a fair die. And so we're just trying to like

Interviewer/Host

make the die as loaded as I guess my thinking. This is the thing that I think about constantly is how do you bring, you know, basically translation.

Brandon

Right.

Interviewer/Host

And whatever the equivalent is in materials. So how we name that that I really want to see a model that thinks about. These are the factors that and reasons about and is very good at saying I'm filtering my Designs to the ones that I think are going to make it through phase three. Right.

Rafa Gomez Bombarelli

My wife is a translational scientist in biotech, so she reminds me very often like you guys should be doing AI for translational science. In a sense, I, I think that's sort of some of the echoes, especially in the materials and chemistry our tools can call process engineering simulators and go figure out what pipe diameters and what heat exchangers you should be using in order to scale up the process for the economics to be worth it. So still maybe there is, I don't know if we're going to gank up a filter until we go measure it, but the ability to reason now about the things that will come downstream, which is sort of a little bit what the translation of sort of AI would do is reason now about sort of what's going to matter. Because I. When you said earlier, when you have the ind, you're locked in, and it's true on the chemistry side, the molecule, the sequence you've chosen, of course, which population you're going to give it to and how you're going to measure success, those choices you make afterwards.

Andy Beam

Right.

Rafa Gomez Bombarelli

And, and I would say I don't work on the preclinical stuff, but on the chemistry and materials. That is precisely the type of behaviors we're trying to instill now with the verifiers and the data sources that we can access, either because somebody has thought about them, either because the physics allows it, or because we can measure good enough proxies now, that tells us what's going to happen later.

Andy Beam

And to be clear, all those things are things that we talk about internally a lot. We're already on the verge of being pathologically overscoped.

Interviewer/Host

Just give me more, give me more.

Andy Beam

But absolutely like the belief that we have is that as models get smarter, as they ingest ClinicalTrials.gov, as we partner with pharma companies and get access to that cookie jar, these probabilities will meaningfully change. On the biomanufacturing side, having access to good manufacturing processes, scale up processes too, we think the models will be able to contribute there. We've just chose to focus a lot of our commercial and collaborative activity on the sort of like frontier of science that we think we can address now, but the goal is to push past that.

Interviewer/Host

If I may summarize it kind of like it's a tool call.

Andy Beam

Yeah, it's all tokens. It's all tool call. Tokens and tool calls are all you need.

Rafa Gomez Bombarelli

But also the reasoning mechanisms that Maybe you mentioned for that doctor that treated, you know, the IL antibody, IL6 antibody that you mentioned. Well, that person had learned that from, you know, a combination of lived experience and reading the literature. And we get, since we believe our thesis that the breadth gives us depth. We will get better at those things

Andy Beam

by doing more things in so many counterfactual worlds. That doctor was not the one treating Emily Whitehead. In that case, NCAR T may have looked like it may have been yet another gravestone in Eroom's law, you know, for, you know, yet another failed drug. So I do think that like that went from like a 2% success probability to a 98% just because that person happened to be in the room. And so if we could just operationalize that again like the. You, you, you're going to move a lot of probabilities.

Interviewer/Host

Yeah, so that's a, that's a good example of where just having really broad knowledge of scientific information. So that's like, that's almost like Google

Andy Beam

because that was only being used in pediatric arthritis, like another like very niche area of medicine.

Interviewer/Host

I see.

Andy Beam

Yeah.

Brandon

So you have Ken Stanley and your team famously wrote the book why Greatness Cannot be Planned and is very big on open endedness and serendipity in ML research. So what is the role of open endedness at Lila?

Andy Beam

Oh yeah, one like Ken is awesome. So for those of you who don't know, Ken pioneered an area of machine learning and AI called open endedness, which I think of as machine creativity. Like how do we get models to do open ended exploration and also like have a sense of taste about what's interesting things that should go down. So you can't have scientific superintelligence if you're just a good test taker. So if you think about what reinforcement learning is doing, even at scale, it's answering questions in kind of like a ruthlessly Vulcan esque Spock kind of way. But you probably only in limited ways would think of that model as being supremely creative. And so Ken has created or built an open endedness team at Lila to sort of take the outer loop or the meta part of that reasoning challenge on. So how can we get our models to not only be able to answer tough questions but ask interesting questions in the first place. And so that's really Ken's mandate. He's been building like a world class team over the last like several months and they're in the kitchen cooking now. And I think by the end of this year we'll have some cool stuff from Ken's group to share. So we're going to hop into a video here of the lab. This is going to show a couple of different things. Okay, so that's probably a peeler or a sealer. So when you move plates from instrument to mention, obviously there's liquid in it. Most of biology is wet. So you put these stickers on it. So that was a plate being sealed. All right, so here we go here.

Interviewer/Host

It's picking up a. Yeah, so this

Andy Beam

is inside of a liquid handler. Let me go. We'll wait till it gets to a wider shot here so that you can see the PCI bus and see some of the robotics.

Interviewer/Host

So the liquid handles.

Andy Beam

This is the magnetic. Yeah, so this is the planar motor system here where the plate magnetically levitates. This is the PCI bus where the transport layer connects all the instruments. You can see benches there where all the instruments sit. A robot arm picks it up, is now going to transfer it to a different plate to go on to the next. There's a little bit of a traffic control thing that you have to do here. Like they actually will go and park for a while while trapped congestion clears. And here's a long shot of the PCI bus and. And again, all that's fully controlled, all that's fully automatic. And this is a material science example.

Rafa Gomez Bombarelli

This is a physical science example.

Brandon

Yeah.

Rafa Gomez Bombarelli

Where it takes us back to the scaling point here. It's making our hydrogen catalysts in a scaled up form factor by that's an ink that contains nanoparticles of the material. That's a spin coater as you can guess from the fact that it spins the plates. And then this is a robotic handler moving around little pieces of catalyst to test. And this nice looking purple 90s neon vibe. This is called magnetron spattering machine where we make atoms fly from a source and deposit on the other side of the chamber in a very thin atomic film. Where we can make arbitrary mixers of elements based on what's on the three, four sources. We just vaporize them and make them fly over the chamber and make these nice thin films that are very material efficient. We can do this with very, very little material and is one of the workhorses for us to design, make, test fast in many applications, in catalys, in corrosion, in mechanical properties. Many things you can test in this sort of very convenient form factor.

Interviewer/Host

The liquid handlers and some of those machines, those are kind of off the shelf mostly. And then so the. And then you have this. You've come up with this sort of form factor that works for lots of those, those machines both for material and for bio.

Andy Beam

Quantum dot is a good example of the combination of the two. It's actually a liquid handler that we've repurposed for quantum dot synthesis and end design design. And I think that that speaks to. You can get very far with 20, 30, 40, 50 instruments. The ability they just have to be on platforms that the model can use them. I think a big eye opening thing for me coming into Lila because I wasn't in lab automation in any meaningful way before coming to lila is it's not the automation that I was hoping for. A lot of automation is pointing automation where there is a tablet attached to the side of a liquid handler where you can enter a macro. That device is not meant and sometimes purposely designed not to talk to other things. And so a lot of what we have done has been to. I kind of joke that we have the world's largest collection of voided warranties in biology because we have written our own custom drivers, our own custom firmware to get sort of low level granular control of a lot of these instruments and make them talk to each other. So the video is cool because you see magnetically levitating plates. What you don't see is like the custom software wrapper that stitches all that together. And a lot of this comes down to really hard software hardware interface challenges. Some of the machines literally still run Windows 95. And so think about how you automate that. Like we actually have a vision language model controlling a Windows 95 machine because that's the only way to automate it.

Interviewer/Host

I was going to joke about a mechanical finger pressing buttons, you joke.

Andy Beam

But no, we did that. We actually did use a robot to push the iPad on the side. I think the other thing to like, the other thing to call it here is this is still automation made for people. Like the instruments sit on benches which are approximately chest high because there's the assumption that someone needs to reach in there to service it or to fill the reagents. So this is the like V0, V05 what we think lab automation will look like. And because we've just decided to vertically integrate and own the hardware software stack, the V2 will look very different than this where we'll be able to integrate things. This is happening already on material sciences because those capabilities just don't exist. And we often think about labs in terms of their XY coordinates as we integrate. We'll have a Z component too because we'll be able to stack Things again, tokens per unit volume is what we'll be thinking about then. But we think that the lab of the future should not be made for people to easily walk into it. It should feel like a data center where you go and you see the rows of server racks, there's room for a crash cart behind it to service the network nodes. But it should be as densely packed as possible and you know, also as energy efficient as possible and things like that. So, yeah, so we're, to answer your question, we're using commodity things now because it makes sense to get started. But over time, almost surely the form factors of those will change quite a bit.

Interviewer/Host

I see. I'm just a little surprised that you can come up with this common size of tray that kind of matches your needs for a good percentage of your problems.

Andy Beam

Well, it's just working backwards. 960 well, plates are the atomic unit of experimentation and lab automation. And so we now do 96 well form factors for material sciences. As a result, not everything fits into that form factor. But again, the coverage that you get from adopting a 96 well or 384 well plate format.

Interviewer/Host

80, 20.

Andy Beam

80 20, exactly. Yeah, yeah.

Rafa Gomez Bombarelli

I mean you can see some of those where the pieces of deposited material were bigger. So we still use the plate shape to carry them over. But then the number of samples. Right. That you have them are smaller. I think some of them are like maybe 12, four times three.

Interviewer/Host

Yeah.

Rafa Gomez Bombarelli

This takes me also to a point. You folks asked earlier about scaling and sort of how when you scale, your problems are different. And a problem I think we're looking forward to collectively at the company is the orchestration and the scheduling of a data center size AI science factory? Of all the experiments you could run concurrently, how are you going to think about the logistics and the orchestration of moving all these samples and interfacing all these instruments to create sort of the maximum value for our customers and maximum information for our model. And that's the exciting part that probably is going to look very different from some of the other problems we're thinking about now.

Andy Beam

What we think about, Rafa said, is like orchestration on top of that is like a slurm queue or something like that that lets you globally maximize throughput of the system that you have. But again, using those same abstractions to think about throughput, scheduling, orchestration. And as the system gets complex or gets larger, the complexity in maximizing that throughput. So if you're like a csp, a constraint satisfaction problem, Nerd. We have one of the coolest ones to think about.

Interviewer/Host

Are you thinking about scaling as that one cluster and then you just cookie cutter that or is it like I have all of my liquid handlers and all of my whatever spin coaters and over and in different parts of the lab or something.

Andy Beam

I mean currently what we have essentially is one big fully connected graph and that won't scale indefinitely. Just some of the material stuff use throw off hazardous fumes and so that's isolated for safety reasons. I don't know exactly what the exact configuration and layout of the science cluster of the future looks like, but I think that it will probably have fewer instruments on it than you might guess. You would need need hundreds, maybe thousands. But we do think about scaling it in the same way that you would think about scaling a data center in that it's a multi level building, occupies millions of square feet and it's like a lights out facility as they say. It's like running 24 7, generating data in real time and you would want the same uptime you would expect of a data center. Now that's very hard to do. That's like an insanely hard thing to do. But that's the end point that we're trying to work backwards from what problems do you need to solve on those way to that, like that endpoint.

Brandon

No, this goes back to my previous question though about like the runtime of your experiments too because scaling means different things and one of them is experimental design which intrinsically scales, but maybe at the cost of signal noise ratio or some other idea. But you know, getting broad data quickly and efficiently at some cost or scaling is, you know, lower throughput, but just parallelizing, you know, wildly. So like in general I would approach those as two different sets of problems. I don't think that general, the same strategy really works for them in general. So like what types of scaling is more important for you as a scientist?

Andy Beam

I would say like round over round iteration is more important than like a broad, hugely multiplexed, highly like noisy kind of thing.

Brandon

So iteration time is really the single. Exactly thing. Yeah.

Andy Beam

Yeah.

Brandon

Okay. Yeah. So does that limit the domains that you, you want to focus on? Like you know, now do you think like if we are going to try to tackle a new problem, do we ask can we just solve this problem with fast iteration versus something where maybe this. The answer is will you scale up by you know, massively multiplexing something but with like month long turnaround?

Rafa Gomez Bombarelli

Parallelizing and multiplexing are though, are somewhat different, right? Some, I would say pooled. We love pooled.

Brandon

Yes.

Rafa Gomez Bombarelli

Pulled we love because it's. You get fast and broad. So what is pooled made for pooled are things like DNA encoded lines, libraries

Andy Beam

where you use each well has a bunch of crap in it. Then you can sort out the crap after you do the experiment.

Rafa Gomez Bombarelli

Somehow the form of the assay allows you to throw a thousand or a million or a billion experiments at the same time. And the way the assay is set up, the readout picks the winner. So you try a million things in one plate and you get one readout or a thousand readouts of the thousand winners. Multiplex.

Brandon

There's a joke that all biotech is just mapping whatever readout you want to on NGS sequencing.

Rafa Gomez Bombarelli

Yes.

Brandon

Tag it, you know, multiplex. There you go. Yeah, you can get lots of data.

Rafa Gomez Bombarelli

The other argument would be that if the standard for a field is a month and it's going to take us four days, a four day learning cycle is amazing because it's sort of, it's really going to move the needle for that part of the field. This is where our automation engineers and our teams are thinking about other ways of measuring things. And you know, in coolants and in catalysis there are places where we just made different instruments that measure a different property that turns out response a thousand times faster. For instance, in sorption, I can tell you folks a little bit, in gas sorption people typically measure, they pressurize an amount of gas. Well for the MOF and cough materials I was talking about sucking CO2 out of the air, you know how much from the ideal gas law, if you remember high school, you know how much gas you put in the little box and then you wait for the gas to be absorbed in the material. You check the pressure and from the difference in pressure you know how much went into the, into the thing. Then you up the pressure again and you see how much extra weight. And if this sounds slow, it's because it's very slow. It's called bet. This is about day per sample and it's very tough to parallelize because it's another gas line, another canister. Or you can take other types of proxy measurements from other instruments that are parallelizable. And that's something we built in the lab now where instead of measuring pressure, we're measuring another property we care about that is a readout for what actually pressure would tell us. But we can do 96 well plates for 96 metal organic frameworks in like an hour. So it's like maybe 2500 times faster. So this is A place where there's a little bit of room for ingenuity or just, you know, an hour is still slow compared to other readouts. Right. Other things in electrochemistry maybe we can do in a minute, but now we're sort of, you know, a thousand times faster than the way we were doing it.

Andy Beam

I think the answer to your question also too depends on how much we think the model is starting from a dead start versus a walk versus a jump dog. So if there's some area that we care about, some question, it's clear there's like zero knowledge in the weights of the base in the model that we're using, then we may prefer a big slow thing to move it. And if we think that it's already relatively competent in that, then we would vastly prefer the RAID serial fast iteration cycle. So we will do both. The bet is that the sort of like as the model performance improves, the sample efficiency goes up and therefore the compound interest that you get from round over round experimentation will outweigh that that you would get from a big noisy but broad data set.

Interviewer/Host

So do you have any concern? This is, I'm just thinking out loud here, but do you have concern that you're going to quickly sort of saturate the problems that you can solve using concern or hope? Like concern and hope? Maybe, but the maybe you have these systems that you're putting in place and right now, because they're new, then there's like a lot of green field. You can go and tackle all these problems that are amenable to high throughput experimentation. You're going to do that for a couple years maybe. And then all of a sudden now the like everything is different and you have to like completely retool your, your like gazillion dollar.

Andy Beam

I mean I hope that that is true to be fair. Like, so I hope that we don't have to measure a binding KD again in two years. Like if we to do that, like, I'm very pumped about that because the model has essentially mastered binding kinesis.

Interviewer/Host

So you think that eventually you get to the point where the model knows how to do that.

Andy Beam

Let's go back to the PCI bus again. So like what we actually want to do is to reduce the amount it takes, the time it takes to bring a new instrument on platform. So you want that to feel a lot like a usb. I don't know how old you guys, but like when I was old, I mean when I was a kid, you got a new device, you got the drivers on a Floppy disk, you had to beat your head against the wall to get the driver to install and days later your printer only kind of works. So that's kind of what like. Yeah, exactly.

Rafa Gomez Bombarelli

And if you're a Linux hardcore person, you can still live that experience.

Andy Beam

Today your audio driver still doesn't work. So that is like what it's like to bring a new instrument on platform in biology and physical sciences now is that we're in the like driver on a floppy disk and the manual to try to get to work. So again, one of the things that we hope a unified platform enables is instrument onboarding. Time eventually goes to zero, where you have the spec from the manufacturer, the model reads it, the right APIs get abstracted. We're working with some instrument vendors to make this process easier. But I think a lot of the way that we think about modulating a system is conditioned on how we do it now. And so again, we're hoping that a unified platform makes onboarding instrument two years from now a 30 minute exercise versus a 30 day exercise. Again, it's a hard thing to do, could be wrong, we might do not be able to do it. But that's the future that we're pointing to where currently we actually can swap out existing instruments very quickly. So if we need to replace a Hamilton with a different liquid handler, that swap actually happens very quickly already. And so we do have some reasonable belief that onboarding new instruments will get faster, better, more reliable over time. And again, we don't want to be doing 2026 science in 2036. And so we hope that some of these instruments get deprecated or the way that we're measuring things change, changes. Otherwise, lots of assumptions we and everyone else made about the rate of progress in the next decade will have been wrong.

Interviewer/Host

They were wrong.

Andy Beam

They will have been wrong.

Rafa Gomez Bombarelli

And we're already benefiting from the instrument vendors. I wish the problem we have is what you're describing, that we run out of science to do with the instruments. How do we have the ante for the instrument vendors? The instruments we have now are as powerful as a beamline would have been 10 years ago. We're taking measurements today that 10 years ago would have requested you to ask the federal government for a time slot at 2 in the morning somewhere out there to waste a couple of nights of sleep taking measurements at a really bright neutron or X ray source. And today the vendors make instruments like those that we can put next to the quantum dot or next to the protein expression. So yeah, I wish that's an end state that is decidable but very, very unlikely. I'm sure there's going to be new science to be asking of the instruments we have.

Brandon

We've had guests who have had both of these themes of first of all, none of the devices you buy are set up to do high throughput AI science. And also that there are new scientific devices which come up every day which just like open up something which was impossible like 5, 10 years ago, like inline NMR.

Rafa Gomez Bombarelli

There is lots of sort of characterization, miniaturization and sort of more resolution, more bright sources that are just transformational and they might read really well with a kind of automated high throughput science we're doing.

Andy Beam

So we're moving into this facility in Cambridge, in Alewife, Massachusetts. And it's just a 3D rendering, it's 100,000 square foot space. And we will move towards AMRS autonomous mobile robots as some of the transport. And so you can see some of that there.

Interviewer/Host

We'll put it in the show notes.

Brandon

Okay, so kind of switching topics a little bit. So you were talking about your scientific pile of 10 trillion tokens. When I hear 10 trillion, my first thought is man, that sounds like a lot. Things like this is 30,000 human genomes, which would cost roughly 3 million to sequence. It is roughly 1 2,000th of several of these large foundation models like EVO and nucleotide transformer and so on. So in some sense it is a lot of data. In other sense it's not a lot of data. And there are certain, not all tokens are the same. So I'm curious what went into creating this? What were your thought processes and then how much actual useful information is integrated? 10,000 tokens or 10 trillion tokens.

Andy Beam

Yeah, so it's tokens in the same way that we think about counting post trade tokens from the Internet or from post training runs. So these are again like RL is the best way to think about. RL is a data generation mechanism. It's a way to steer the model towards more and more valuable tokens, like better tokens. And so these are the result of running that process across many different scientific RL environments at Lila, where the tokens are a mix of English tool calls and experimental feedback. So they're quasi English tokens, as we've been talking about, tokenized by the tokenizer. So that's where they came from.

Interviewer/Host

So you're not tokenizing like. So we're not implicitly.

Andy Beam

Because if the model is asked a question about DNA, there are DNA tokens in There it's not like we downloaded dbgap or the PDB or SwissPro or something like that. And tokenized at the sequence level. These are reasoning tokens, model generated are experimentally verified.

Brandon

On top of this you also still have your alphafold, your nucleotide transformer, you have all your sequencing data which goes into this. So 10,000 tokens is 10 trillion, say 10 trillion. I'm like looking at Tin T on my laptop.

Andy Beam

The reason why we think that level of data is important, pre training corpuses are usually somewhere between 15 and 30 trillion tokens. And so that's the scale at which you see these emergent things happen. And so once you're in sort of the trillion token regime, we feel confident that that's enough for the mod to start to master and see emergent capabilities.

Interviewer/Host

Are you starting from scratch with your model or you have some open source model?

Andy Beam

Again, in the interest of being ambitiously over scoped, but not pathologically. So we have not decided to take on pre trading as well, just because the black magic that you have to do is insane. And we've been gifted something like a billion dollars worth of compute in the form of open weight models. So we start with an open weight model that has been traditionally pre trained and the assumption that we are making is that the model has been pre trained on the Internet in a large fraction of the scientific literature. Therefore it's a good scientific prior over what is known and therefore a good base camp to build upon.

Interviewer/Host

So it's 10 trillion on top of the trillion to the bin.

Andy Beam

And we use Numitron quite a bit because we have a partnership with Nvidia and I think there's like 30 trillion tokens that go into the pre and post trading for that model have you all taken.

Brandon

So in the process of these reasoning tokens you are also creating what are arguably probably just rather useful data sets themselves. Have you thought about independently releasing some of those data sets open source, even in the absence of the reasoning model, which may still be quite valuable to community, but doesn't actually deteriorate, break your moat at all.

Andy Beam

So one of the things that we've developed along the way is a test suite of something like 1000 unique scientific RL environments where you can drop in front of frontier model, you can drop in your own model, we drop in our models. So almost surely we're going to open source a subset of that. Some of it based on data that we've generated, some of it that we have curated for the community to use. So there will be some open source version of the benchmark that we've assembled that's doing part of that. And there will be probably some training data that goes along with that.

Brandon

Cool.

Interviewer/Host

Do you have benchmarks internally that actually

Andy Beam

operate the lab essentially like a benchmark for how well does maybe another way of saying it.

Brandon

Do you have experimental, automated experimental controls? Yes.

Rafa Gomez Bombarelli

I mean we have I think for every of the we've put together from the beginning of the company sort of these multidisciplinary teams to work on a specific sort of close ended problems and the modus operandi has always been to benchmark training. Something naively for from zero calling Frontier, the frontier models that everybody would go sort of use right out of the box on our own internal. So with everything we've done, we do have an internal benchmark now. The domains are very specific. Right, Right. They're not as general and all encompassing as the benchmark that Andy was describing because they are the things we really care about and the products that we want to deliver and sort of the places where we want to make a difference. But in all those places we've typically seen that the scientifically pre trained model that Andy is describing with access to tool calling typically demolishes. Of course anything else that would look.

Andy Beam

I mean it's worth thinking about what we're trying to do, how that is additive. With LLMs, if you think about an experimentally verified reasoning trace, how many of those do you think exist on the Internet or in the preference training Corpus

Brandon

order of 0, order of 0.

Andy Beam

It certainly rounds down to 0 versus the next order of magnitude. So like we have just seen incredible lift from showing the model that even if we're at like a parameter disadvantage relative to the frontier models, just showing it in experimentally verified reason reasoning trace you. You see just immediate lift when, when we do that.

Brandon

Lila is a flagship company. Flagship is like basically one of the biotech incubators in the world. You have had something like what I think 30 successful IPOs or not you, but your parent. Yeah. You know, world, including you yourself were just part of Generate Generate biomedicine and just had a successful IPO very recently. So you know, Lila is very good at biotech. I would say from history it's very much single asset.

Andy Beam

You know, traditional flagship is very good at biotech.

Brandon

Flagship.

Andy Beam

Yeah.

Brandon

But I just say w W yeah, flagship is very good at biotech has, you know, very historically been very focused on single assets. I guess in the last few years with Generate with, with I guess Expedition Valo, There are some branching out into more platformy things. Y. I'm curious about one how does Lila fit into the broader flagship ecosystem? Was there a specific reason why Lila is now, like, why this sort of pivot from single asset into scientific reasoning and like, what is the broader interaction like? In particular, you mentioned that, you know, you had a drug which was or you had a car t drug which was at the level of ind. So, you know, you clearly have the ecosystem to make that into something. So I'm curious, like, well, you know, maybe like, where is this going?

Andy Beam

Yes, great question. Let me do a little flagship framing and then I'll sort of talk about. So we all start as the same pluripotent stem cell, but there's differentiation that we all take. The traditional path for a flagship company is there's. So the history of Generate is. I was an early advisor to Generate, a consultant over 2018. There was this idea to use machine learning for protein engineering. Me and a couple other folks at Flagship and some other external folks who came in. Dartmouth professor named Gavor Gregorian was part of this. Got seed money from Flagship Flagship to then go and spin that out. We worked on building the technology and then usually the deal is that Flagship is the sole investor during a Series A and then the Series B is normally the first point at which external capital comes into that. To your point, they often end up being asset based companies. Generate has a phase three trial for monoclonal antibody to treat asthma. Phase one behind that to treat copd. I think the recognition from some folks at Phytop, especially our CEO Jeff and Maltzen, he had created, been involved in creating a lot of these companies and he's like hiring the same team over and over and over again. You need the ML team, you need the platform team. And so I think he saw shared DNA between all these companies and like, let's have one company that can essentially support all these different things. Year one of Lila was essentially like when O1 dropped. And so we had all these pieces in place and it just became clear that we could create a platform to support a new kind of scientific model. In the early days, we didn't know how do you monetize that? What's the commercial strategy? We've gotten a lot of clarity over that over the years, but sort of the core conviction that we had two years ago was the bitter lesson is correct. Science could be an infinite token generator. Operationally, the way that we're different from a normal flagship is outside investment came in before the Series A. Again, the Lead of the Series A was not flagship. So we do have that lineage. We do come from both Boston. We, we do have a lot of the shared learning that what a company that has created 110 startups that I think so they, they normally so generate was FL5657. It was actually a merge in the early days. Lila was 96, 97. And so the flagship has this enormous, this, you know, long history of creating companies. So we have that network and we have the learning of leaders who have created that many companies. But we, we're such a weird creature that we essentially went down a very different path very, very early.

Brandon

So why is it that when I hear, you know, you have a very promising car T therapy, like you said, you had a dc, like why not just, you know, partner with that out, Partner that out. Or maybe this is on the horizon or something.

Andy Beam

But the short answer is that, is that we, we, we are engaging in commercial partnerships around car T therapies for sure. Some of them are further development to increase some of the, or change some of the properties. So like, you know, bispecifics and things like that, going after novel indications. But we've used that one car T to essentially launch several partnership programs.

Brandon

So this is sort of like the proof of principle. But it itself was not, you know, quite exactly where you what a drug needed to be or something.

Andy Beam

Well, so just like to be clear, like we could go and try and license or partner that specific thing. We found that it was better to take that and secure several partnerships around further development.

Brandon

I see. Okay.

Andy Beam

Yeah, cool.

Interviewer/Host

You're getting a. Basically you're, you're doing some sort of code development thing.

Andy Beam

Well, this is the, this is the virtual startup idea where company starts a virtual startup around one of these indications and they essentially pay us revenue to further development. And again, we have these milestones and things around it. Yeah.

Brandon

So like long term, since flagship is specifically bio and is never really branching the materials, how does that sort of weight flagship or Lila's strategy? Does that play into it at all or is like at this point you've kind of launched and sort of, it's

Rafa Gomez Bombarelli

one of the reasons why it's sort of differentiated into something different so quickly. Right. I think part of, you know, the breadth of the mission clearly was beyond BioTech. From day one, the people we needed to hire came from different networks. The instruments we had to buy came from different vendors than the flagship vendors would have usually been. So I think that was part of sort of the reasons why it feels Somewhat different, but it's also core to the mission. We cannot get this to work on a narrow field. By definition, we want to be as broad as we can post because that's where the, where the emerging behaviors are going to come from.

Andy Beam

And I think if you looked at the composition of people who work at LILA now, it would look like categorically different than what you would expect like a median biotech company to look like. So we, we hire out of or compete for and sometimes win against people who are considering frontier lab offers. We have a heavy software engineering and tech presence. The amount that we spend on GPUs would be atypical for a biotech. I will say, I think that if we called ourselves a biopharma, we probably would have a top three GPU cluster in the world. It's true that that's part of our DNA, but we've been intentional about trying to make decisions that put us on what we think is the most promising trajectory for life. So this isn't just like kids rebelling against their parents or something. We think that the thesis is right and it points towards a very valuable but also important company for not just biotech, but for materials and chemistry.

Brandon

Okay, that brings me to what I think is my last question. What's harder, materials or biology?

Rafa Gomez Bombarelli

They're actually very different. It's funny, I feel like we're about

Andy Beam

to do the Spider man meme and like

Rafa Gomez Bombarelli

I was around for the first merry go round of AI for the more molecule drug discovery. I mean the atom wises, right. The generates, you know, the in citros. So I think that the hardest is the thing that is the small molecule has all the difficulties of chemistry, of knowing, reasoning over synthesis. And then it has all the difficulties of reasoning about biology and adverse effects and immune system.

Brandon

Yeah, but the counterpoint being that we have so many tricks in our toolkit which you can borrow from biology. Right. So it's harder, but you also have.

Andy Beam

Well, I think think materials are harder so they have the benefit of great simulators that we don't have in bio. Well, I think materials are harder so they have the benefit of great simulators that we don't have in bio. In material science you don't have the mature high throughput automation that you have in biology. For me, materials as a subject is interesting because there's not a unifying principle like the central dogma. Materials means lots of different things. I actually still don't quite understand the unifying principle when we say material science, like what exactly that means. And Then the commercial dynamics are completely different. Like, like again with CAR T we know if we wanted to like how to monetize that directly with material. There's this supply chain, there are devices. The testing that you do in the lab is only partially predictive of like the lifetime of how that material will be used. And the math is harder.

Brandon

I mean like in terms of supply chains still matter for both. You know, maybe you replace clinical trials with some, you know, product validation and verification. I guess qualification is the term. Um, so like there are direct analogies and there, there are hard parts for both of them.

Rafa Gomez Bombarelli

The economics are very different. Like if you pass a clinical trial, you make money. You're gonna like that thing is valuable and kind of how much it costs to make it is very rarely the blocking element. It can be for em.

Andy Beam

It's much easier to underwrite an asset in biology than it is in materials.

Rafa Gomez Bombarelli

Do you guys know the name of a company that makes a superconductors? You know, this always comes up. Are you guys doing superconductors? Yeah, we care about magnets, we care about superconductors. That really cool, cool science. Do you folks know the name of a company that makes super cool? Nobody knows like these things are super.

Andy Beam

I know that they're using MRIs.

Rafa Gomez Bombarelli

Exactly.

Andy Beam

That's the only commercial application.

Rafa Gomez Bombarelli

But it turns out right, like these things, when you succeed, you kind of are. When you make up a cool material that does something, you're kind of a nameless company that makes it sing and it's successful and has good cash flows, but you don't get to break sort of, you know, everybody knows a big pharma, but other than, you know, you've got your three M's, right?

Andy Beam

Yeah. And like most of the big material companies are behind closed doors. Like most of commercial engagements look like getting them to tell you what the important problem is. And there's like less of an open innovation ecosystem. There's a couple things in materials that are obviously recognized to be valuable but like it's just I think very different than life science.

Rafa Gomez Bombarelli

And maybe one of the last things that we haven't touched upon a lot and I want to flag out, I think in chemistry and especially materials, government sponsors research is a big driver. So in the same way that the government doesn't feel they need to do drug discovery other than through funding NIH for early stage open science, hypothesis driven science, the government and national security drive materials innovations in ways that are unique. And you see this in the way we engage with the British government We have partnerships, we work with the US government, we have awards, we partner with, participate in sort of developing materials and technologies, which is a different part of the ecosystem that drives innovation. That's also different.

Andy Beam

Yeah, definitely.

Interviewer/Host

Are you guys working in Mission Genesis?

Andy Beam

We were one of the named partners. We've had an ongoing exist relationship with a lot of the national labs and so we have been working on that

Rafa Gomez Bombarelli

with this N25 Genesis lighthouse proposals last win. So yeah,

Brandon

it.

Andy Beam

He left academia thinking grant writing was behind him. Only to. After I took five of them.

Rafa Gomez Bombarelli

Yeah, I expect about 20,000. Yeah.

Interviewer/Host

The question that we like to ask all of our guests is if you could remove a bottleneck in your domain by and you can define domain by fiat, what would that bottleneck be?

Rafa Gomez Bombarelli

To me, I'm going to go to old timey Rafa that was doing physics based simulation, I would say the sim2real. I think sim2real for the people that come from the physics based world, I think the SIM to real having like an actual.

Brandon

Explain what that means, what I mean.

Rafa Gomez Bombarelli

So these people have typically meant it in the context of robotics where your virtual simulations in 3D spaces kind of allow you to train robots that will move in physical spaces. But there is a gap and they call it the sim2real gap for us in physics based simulations is that we do molecular simulations of GUI stuff, we do electronic structure simulations of hard stuff and they're okay, but they're not predictive enough. And this is the reason why if it wasn't for that, maybe we wouldn't have had to make a self driving lab for materials because we would have been able to just predict. So I think we know there's physics, but it doesn't quite go the way to being predictive. Meaning that the models that we train on physics cannot possibly close the gap either because they're still missing this. They're trained on approximations that are just not good enough. So I think the thing we'll be chasing for decade in AI for materials has been sort of if we train on computational data, can we answer real world experimental questions? And that would have been the place where if I get to also go back in time, in addition to taking the bottleneck out, it would be the accuracy of the underlying simulation that we've been training on all the time.

Brandon

So this is sort of like Heather Kulik said, there is no Alphafold for materials.

Rafa Gomez Bombarelli

Well, the funny thing is Alphafold was trained on experiments. So it's a different. I mean that's funny. She and I, we both come from doing physics based simulations and the fact that she called out something that had no simulations in it whatsoever, it's kind of admitting the same underlying issue, which is like all these, you know, meta has produced tens of millions, hundreds of millions of training data points, but they're all virtual simulations that just don't carry enough water for the thing we actually want to do.

Andy Beam

This is going to be like a boring and obvious one, but, but like there's a metric that you use to track how efficient your training runs are. It's called mean flop utilization or mfu. So the GPU comes with an advertised like peak flop throughput, which is under the best situation doing a calculation that you don't actually care about. How many floating point operations can you do per unit time? MFU is always a very small fraction of peak theoretical flops. And for reinforcement learning it's always somewhere like around 5 to like 6, 6%. So said differently, that means that we're getting like 5% of the actual GPU computing power that we're paying for. So if I could buy Fiat Wave a wand and make our stack perform at like 100% mean flop utilization, I would do that because we would one get to the answer faster, but then also be able to buy fewer GPUs and redeploy that capital to the, to the lab or something like that.

Interviewer/Host

That's interesting though, because your rollouts, aren't they consistent, constrained by the lab?

Andy Beam

They are, but when we train a big model. So RL training pipelines are very complicated. So one way to think about how you would do this at scale is just to have the model doing rollouts left and right, waiting for enough trajectories to pile up and then back propagating that into the model. A different way to do that would be to factorize that, have a bunch of expert models that are trained in parallel that are either generating data or being trained themselves. And then you distill that back into the central, central model. And second way is the most efficient, the more efficient way to do it because all those things are happening at different timescale. And so it's that big. When you have the 10 trillion tokens and you want to push them through the model as efficiently as possible, you're still going to be doing some reinforcement learning on top of that. So if we could get all the flops that we're paying for, I would buy Fiat. Declare that cool.

Brandon

Well, yeah, before we end, is there anything you want to leave the audience

Andy Beam

Audience with, let me say, like why we're here. So we have an office in San Francisco now. It's 181 Fremont street in downtown San Francisco. There's currently 2020 ish, 30 ish people who sit there. But we are looking to expand that aggressively. We're looking to pull from sort of all areas of the stack. So both like post training, obviously, aggressively hiring for that. Folks who've been working in domain AI, like life sciences and material sciences, we're also hiring for that. No wet lab here currently, so it's all comput work. But if any of this stuff that people have heard about today sounds interesting, feel free to shoot either me or Rafa message if that sounds interesting.

Interviewer/Host

Thank you for being here. Really, really fascinating conversation. Appreciate it.

Rafa Gomez Bombarelli

Thank you for having us.

Andy Beam

Yeah.